interfere with表示干扰，指阻碍某件事的进行，例如The noise interferes with my work，意思为那噪音干扰我的工作。interfere in表示干涉，指自行干预别人的事务，例如I never interfere in his affairs，意思是我从不干涉他的事务。
例句：1、She had no right to interfere in what was plainly a family matter.
2、I try not to let work interfere with my personal life.
3、The police are very unwilling to interfere in family problems.
4、Don't interfere in what doesn't concern you.
5、There is a fine line between showing interest in what someone is doing and interfering in it.