interfere with表示干扰，指阻碍某件事的进行，例如The noise interferes with my work，意思为那噪音干扰我的工作。interfere in表示干涉，指自行干预别人的事务，例如I never interfere in his affairs，意思是我从不干涉他的事务。
例句：1、She had no right to interfere in what was plainly a family matter.
这事明摆着是别人的家务事，她无权干涉。
2、I try not to let work interfere with my personal life.
我尽量不让工作干扰我的私生活。
3、The police are very unwilling to interfere in family problems.
警方很不情愿插手家庭问题。
4、Don't interfere in what doesn't concern you.
不要管与自己无关的事。
5、There is a fine line between showing interest in what someone is doing and interfering in it.
关心别人正在做的事情和进行干预之间存在着细微的差别。